Changhai Ding Selected Research

2- (7- (3,4- dimethoxyphenyl)imidazo(1,2- c)pyrimidin- 5- ylamino)nicotinamide

3/2022

Investigational spleen tyrosine kinase (SYK) inhibitors for the treatment of autoimmune diseases.

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Changhai Ding Research Topics

Disease

41	Knee Osteoarthritis 06/2022 - 10/2005
33	Osteoarthritis 01/2023 - 06/2002
22	Pain (Aches) 06/2022 - 12/2002
14	Inflammation (Inflammations) 03/2022 - 11/2006
13	Rheumatoid Arthritis 01/2022 - 12/2002
8	Autoimmune Diseases (Autoimmune Disease) 03/2022 - 05/2006
6	Synovitis 01/2022 - 10/2017
5	Vitamin D Deficiency 12/2019 - 09/2010
4	Osteophyte 05/2020 - 12/2009
4	Disease Progression 11/2018 - 08/2012
4	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/2008 - 05/2006
3	Neoplasms (Cancer) 12/2021 - 01/2017
3	Crohn Disease (Crohn's Disease) 05/2008 - 02/2003
2	Carcinogenesis 01/2021 - 10/2009
2	Obesity 10/2019 - 01/2010
2	Necrosis 12/2016 - 04/2013
2	Cardiovascular Diseases (Cardiovascular Disease) 07/2015 - 11/2006
2	Arthralgia (Joint Pain) 11/2014 - 04/2014
2	Osteoporosis 11/2014 - 05/2008
2	Infections 12/2010 - 09/2006
1	Overweight 05/2022
1	Type 2 Diabetes Mellitus (MODY) 05/2022
1	Neoplasm Metastasis (Metastasis) 12/2021
1	Urinary Bladder Neoplasms (Bladder Cancer) 11/2021
1	Sarcoma (Soft Tissue Sarcoma) 01/2021
1	Arthritis (Polyarthritis) 01/2021
1	Serositis 01/2021
1	Insulin Resistance 01/2020
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2020
1	Cognitive Dysfunction 08/2019

Drug/Important Bio-Agent (IBA)

15	Vitamin D FDA LinkGeneric 01/2022 - 12/2009
7	Biomarkers (Surrogate Marker)IBA 04/2022 - 05/2008
5	Pharmaceutical PreparationsIBA 05/2022 - 08/2003
5	C-Reactive ProteinIBA 01/2021 - 04/2013
5	Monoclonal AntibodiesIBA 12/2016 - 05/2006
5	25-hydroxyvitamin DIBA 03/2016 - 11/2010
5	InterleukinsIBA 01/2016 - 02/2003
4	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2021 - 06/2002
4	Interleukin-6 (Interleukin 6)IBA 04/2013 - 05/2008
3	AdipokinesIBA 01/2022 - 01/2018
3	CytokinesIBA 01/2022 - 09/2006
3	Methotrexate (Mexate)FDA LinkGeneric 09/2020 - 08/2003
3	ResistinIBA 10/2019 - 01/2016
3	hydroxide ionIBA 01/2019 - 08/2012
3	CholesterolIBA 01/2016 - 09/2006
3	belimumabIBA 02/2013 - 05/2006
3	tocilizumab (atlizumab)FDA Link 12/2010 - 02/2003
2	Phosphotransferases (Kinase)IBA 03/2022 - 11/2006
2	Cholecalciferol (Vitamin D3)FDA Link 01/2019 - 01/2018
2	Investigational DrugsIBA 11/2018 - 01/2015
2	Interleukin-17 (Interleukin 17)IBA 03/2017 - 01/2016
2	strontium ranelate (protelos)IBA 03/2017 - 01/2015
2	Biological ProductsIBA 12/2016 - 10/2009
2	LeptinIBA 09/2010 - 01/2010
1	DNA (Deoxyribonucleic Acid)IBA 01/2023
1	cupric sulfide (CuS)IBA 01/2023
1	Vitamin K FDA Link 06/2022
1	Metformin (Glucophage)FDA LinkGeneric 05/2022
1	4- (3- (2H- 1,2,3- triazol- 2- yl)phenylamino)- 2- (2- aminocyclohexylamino)pyrimidine- 5- carboxamideIBA 03/2022
1	6- (2- aminocyclohexylamino)- 4- (5,6- dimethylpyridin- 2- ylamino)pyridazine- 3- carboxylic acid amideIBA 03/2022
1	4- (cyclopropylamino)- 2- ((4- (4- (ethylsulfonyl)piperazin- 1- yl)phenyl)amino)pyrimidine- 5- carboxamideIBA 03/2022
1	ER 27319IBA 03/2022
1	2- (7- (3,4- dimethoxyphenyl)imidazo(1,2- c)pyrimidin- 5- ylamino)nicotinamideIBA 03/2022
1	fostamatinibIBA 03/2022
1	GSK143IBA 03/2022
1	Syk KinaseIBA 03/2022
1	6- (1H- indazol- 6- yl)- N- (4- morpholinophenyl)imidazo(1,2- a)pyrazin- 8- amineIBA 03/2022
1	Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA 01/2022
1	Interleukin-10 (Interleukin 10)IBA 01/2022
1	Long Noncoding RNAIBA 01/2022
1	Peptides (Polypeptides)IBA 01/2022
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2022
1	Biocompatible Materials (Biomaterials)IBA 12/2021
1	Atorvastatin (Lipitor)FDA Link 11/2021
1	fibroblast growth factor 18IBA 09/2021
1	Drinking WaterIBA 07/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Sirolimus (Rapamycin)FDA Link 01/2021
1	turmeric extractIBA 12/2020
1	Cartilage Oligomeric Matrix ProteinIBA 05/2020
1	ORALIT (ORS)IBA 05/2020
1	Proteins (Proteins, Gene)FDA Link 05/2020
1	Indicators and Reagents (Reagents)IBA 03/2020
1	EnzymesIBA 03/2020
1	Citric Acid (Citrate)FDA LinkGeneric 03/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Matrix Metalloproteinases (MMPs)IBA 12/2019
1	Tyrosine Kinase InhibitorsIBA 12/2019
1	Collagen Type I (Type I Collagen)IBA 12/2019
1	collagen type I trimeric cross-linked peptideIBA 12/2019
1	procollagen Type III-N-terminal peptide (PIIP)IBA 12/2019
1	Interleukin-8 (Interleukin 8)IBA 12/2019
1	ProcollagenIBA 12/2019

Therapy/Procedure

16	Therapeutics 01/2023 - 01/2008
10	Knee Replacement Arthroplasty (Total Knee Replacement) 01/2022 - 10/2005
2	Immunotherapy 12/2021 - 09/2006
2	Drug Therapy (Chemotherapy) 05/2020 - 01/2017
2	Replacement Arthroplasty 01/2015 - 04/2012
1	Intravenous Injections 01/2022
1	Injections 11/2021